2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one
LOC14
CAS: 877963-94-5
Molecular Formula: C16H19N3O2S
2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one - Names and Identifiers
2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one - Physico-chemical Properties
| Molecular Formula | C16H19N3O2S |
| Molar Mass | 317.41 |
| Density | 1.390±0.06 g/cm3(Predicted) |
| Boling Point | 528.5±60.0 °C(Predicted) |
| Solubility | DMSO : 25 mg/mL (78.76 mM; Need ultrasonic) |
| pKa | 6.16±0.10(Predicted) |
| Storage Condition | 2-8°C |
2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.15 ml | 15.752 ml | 31.505 ml |
| 5 mM | 0.63 ml | 3.15 ml | 6.301 ml |
| 10 mM | 0.315 ml | 1.575 ml | 3.15 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one - Reference Information
| biological activity | LOC14 is a potent inhibitor of protein disulfide isolerase (PDI), the EC50 value was 500 nM and the Kd value was 62 nM. |
| Target | Kd: 62 nM (PDI) |
| Cell Line: | MTEC cells |
| Concentration: | 0.01 μM; 0.1 μM; 0.5 μM; 1 μM; 5 μM; 10 μM; 100 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited recombinant (r)PDIA3 activity. Improved motor function in HD mice. |
| Animal Model: | Male N171–82Q HD mice |
| Dosage: | 20 mg/kg |
| Administration: | Orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks |
Last Update：2024-04-09 15:16:56
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Tel: 609-228-6898
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Product Name: LOC14 Visit Supplier Webpage Request for quotationCAS: 877963-94-5
Tel: +86-400-900-4166
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QQ: 2881950922
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View History
2-((4-(cyclopropanecarbonyl)piperazin-1-yl)methyl)benzo[d]isothiazol-3(2H)-one
CIS-4-[2-(2-METHYLPHENYL)-2-OXOETHYL]CYCLOHEXANE-1-CARBOXYLIC ACID
4-溴-N-(2-氯-4-碘代苯基)苯甲酰胺
2-CHLORO-N'-(2,5-DICHLOROPHENYL)NICOTINOHYDRAZIDE
Hydrazinecarboxamide, 2-(1-phenyl-5-hexyn-1-ylidene)-
2-Pentanol, 5-[(1,1-dimethylethyl)thio]-
MCH (SALMON)
噻吩[3,2-b]噻吩-2-硼酸
CIS-4-[2-(2-METHYLPHENYL)-2-OXOETHYL]CYCLOHEXANE-1-CARBOXYLIC ACID
4-溴-N-(2-氯-4-碘代苯基)苯甲酰胺
2-CHLORO-N'-(2,5-DICHLOROPHENYL)NICOTINOHYDRAZIDE
Hydrazinecarboxamide, 2-(1-phenyl-5-hexyn-1-ylidene)-
2-Pentanol, 5-[(1,1-dimethylethyl)thio]-
MCH (SALMON)
噻吩[3,2-b]噻吩-2-硼酸